BGB601 (ADCT-601) is an antibody drug conjugate (ADC) composed of a humanised IgG1 antibody against human AXL that is linked to a cytotoxin. In pre-clinical experiments, BGB601 demonstrated potent and specific in vitro and in vivo anti-tumour activity in various cancer-derived models with different levels of membranous AXL. BGB601 is out-licensed to ADC Therapeutics S.a.r.l.
Selective AXL inhibitors
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