is the most common form of acute leukaemia diagnosed in over 20,000 patients in the US annually and is rapidly lethal if left untreated. Successful treatment typically requires intensive therapy or bone marrow transplantation, and relapse and resistance are common. Consequently, there is an urgent need for effective novel therapies in R/R patients, particularly those that are ineligible for intensive therapy.
Phase I/II combination and monotherapy trial of bemcentinib in AML/high risk MDS
BGBC003 is a phase Ib/II multi-centre open label study of bemcentinib (BGB324) as a single agent in patients with AML or MDS or in a combination with chemotherapy (cytarabine and decitabine) in AML patients. Up to 75 patients will be enrolled at centres in the US, Norway, Germany and Italy.Clinical Trial AML