- Extensive data in pre-clinical models of non-small cell lung cancer (NSCLC) and pancreatic cancer demonstrating AXL’s role in reversing tumour-mediated immunosuppression and therapy resistance presented at AACR
- Selective AXL inhibitor, bemcentinib, shown to reverse AXL’s effects, thus acting synergistically with immune cells and anti-cancer therapies
- Data further strengthens broad development opportunities for bemcentinib both as a monotherapy, and in combinations, in a broad spectrum of cancers
Bergen, Norway, 2 April 2019 – BerGenBio ASA (OSE: BGBIO) a clinical-stage biopharmaceutical company developing novel, selective AXL kinase inhibitors for multiple cancer indications, announces preclinical data strengthening bemcentinib’s broad potential in reversing tumour-mediated immunosuppression and therapy resistance, presented by the Company’s academic collaborators at the American Association for Cancer Research (AACR) Annual Meeting 2019 (March 29 – April 3, Atlanta, Georgia).
Leading academic groups from the Gustave Roussy Cancer Centre in Paris, France, MD Anderson Cancer Center in Houston, TX, and UT Southwestern Medical Center in Dallas, TX, presented three posters describing pre-clinical findings generated in collaboration with BerGenBio on AXL’s role in aggressive cancer and bemcentinib’s therapeutic effect. The data presented lend further support to the Company’s ongoing clinical proof-of-concept programme and planned late stage strategy evaluating bemcentinib’s potential as a monotherapy and in combination across several indications.
A summary of results presented is given below.
(1) Salem Chouaib et al, Gustave Roussy Cancer Centre, Paris, France: AXL targeting enhances lymphocyte-mediated cytotoxicity of lung cancer cells. Abstract – 1200
Summary of results presented:
- NSCLC cells expressing AXL were less prone to cell lysis mediated by cytotoxic T-lymphocytes (CTL) or NK-cells
- Bemcentinib treatment led to increased CTL and NK-cell mediated killing of these AXL expressing NSCLC cells
(2) Kavya Ramkumar et al, The University of Texas, MD Anderson Cancer Center, Houston, TX: Targeting AXL sensitizes non-small cell lung cancer to ATR inhibitors by enhancing replication stress. Abstract – 276
Summary of results presented:
- Bemcentinib treatment induces DNA damage and a subsequent DNA-damage response in NSCLC cells in a dose-dependent manner
- Bemcentinib acts synergistically with DNA-damage-repair targeting agents (ATR inhibitors VX-970 or AZD6738) in reducing viability of NSCLC cells
(3) Wenting Du et al, The University of Texas Southwestern Medical Center, Dallas, TX: AXL is critical for pancreatic cancer progression and metastasis. Abstract –1037
Summary of results presented:
- Downregulation of AXL via genetic engineering of pancreatic tumour models resulted in a more active immune microenvironment, prolonged survival and improved response to gemcitabine
- Pharmacological intervention with bemcentinib similarly achieves immune activation and potentiates the effect of gemcitabine in pancreatic models where AXL is present on tumour and stroma cells
AXL kinase is a cell membrane receptor and an essential mediator of the biological mechanisms underlying life-threatening diseases. In cancer, AXL suppresses the body’s immune response to tumours and drives cancer treatment failure across many indications. AXL inhibitors, therefore, have potential high value at the centre of cancer combination therapy, addressing significant unmet medical needs and multiple high-value market opportunities. Research has also shown that AXL mediates other aggressive diseases.
Bemcentinib (formerly known as BGB324), is a potentially first-in-class selective AXL inhibitor in a broad phase II clinical development programme. Ongoing clinical trials are investigating bemcentinib in multiple solid and haematological tumours, in combination with current and emerging therapies (including immunotherapies, targeted therapies and chemotherapy), and as a single agent.Bemcentinib targets and binds to the intracellular catalytic kinase domain of AXL receptor tyrosine kinase and inhibits its activity. Increase in AXL function has been linked to key mechanisms of drug resistance and immune escape by tumour cells, leading to aggressive metastatic cancers.
About BerGenBio ASA
BerGenBio is a clinical-stage biopharmaceutical company focused on developing transformative drugs targeting AXL as a potential cornerstone of therapy for aggressive diseases, including immune-evasive, therapy resistant cancers. The company’s proprietary lead candidate, bemcentinib, is a potentially first-in-class selective AXL inhibitor in a broad phase II oncology clinical development programme focussed on combination and single agent therapy in lung cancer and leukaemia. A first-in-class functional blocking AXL antibody (BGB149) and an AXL-ADC (ADCT-601) are undergoing phase I clinical testing. In parallel, BerGenBio is developing a companion diagnostic test to identify those patient populations most likely to benefit from bemcentinib: this is expected to facilitate more efficient registration trials supporting a precision medicine-based commercialisation strategy.
BerGenBio is based in Bergen, Norway with a subsidiary in Oxford, UK. The company is listed on the Oslo Stock Exchange (ticker: BGBIO). www.bergenbio.com
Richard Godfrey CEO, BerGenBio ASA
+47 917 86 304
Rune Skeie, CFO, BerGenBio ASA
+47 917 86 513
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Forward looking statements
This announcement may contain forward-looking statements, which as such are not historical facts, but are based upon various assumptions, many of which are based, in turn, upon further assumptions. These assumptions are inherently subject to significant known and unknown risks, uncertainties and other important factors. Such risks, uncertainties, contingencies and other important factors could cause actual events to differ materially from the expectations expressed or implied in this announcement by such forward-looking statements.