CELLSELECT Modeling^™

BerGenBio AS offers a range of in vivo and in vitro models. These include:

• Orthotopic human xenograft models for prostate, lung and breast cancers featuring our highly-metastatic in vivo passaged cancer cell lines. Further models are under active development.
• 3D human tissue engineering models with rapid development of functional human vasculature
• Medium-throughput high-content angiogenesis co-culture assay, with the ability to distinguish between vascular disruptive and normalizing agents.

Example Applications

• Drug target discovery and validation
• Application of CellSelectRNAi and CellSelectRegulated in our in vivo disease models
• Development of novel highly metastatic cell lines
• Multiple rounds of xenograft implantation, followed by CellSelectImaging to follow metastasis
• Recovery and culture of tumour cells from metastasis
• Results in significantly increased metastasis and decreased time to progression